New PhD position available – polyglutamine structural biology.

Update: this position has been filled!

26/02/2019: A new fully-funded PhD position in the lab is available in our project studying the structure of polyglutamine amyloid proteins involved in Huntington’s disease. This research position will focus to a large extent on continuing and expanding the structural ssNMR methods that we previously reported in:

• Hoop et al. Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core. Proc. Natl. Acad. Sci. USA. 2016 Feb 9;113(6):1546–51.

This will involve the development, testing and application of advanced ssNMR structural measurements. Aside from the ssNMR development work, structural measurements will be integrated with mechanistic and biological assays, similar to prior our paper:

• Lin et al. Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core. Nat Commun. 2017 May 24;8:15462.

The applicant is also expected to be comfortable with the English language and enthusiastic about working in a collaborative team environment. The ideal candidate would have a relevant MSc degree in physics or chemistry, experience with NMR spectroscopy, and a genuine interest in (bio)physics and protein structural biology. Interested individuals with a different, but relevant, background are encouraged to inquire. Inquiries, questions, and applications should be sent by email to p.c.a.van.der.wel@rug.nl. Applications should include a CV, a cover letter describing your motivation for being interested in the project and contact information for two or three reference writers.

Also posted here.

 

12/03/2019 – update – the funding organisation (Campagneteam Huntington) has posted a news item about their support of this research project.