Starting January 2015, the NIH NIGMS has awarded our R01 proposal on the molecular characterization of the misfolding and aggregation of expanded polyglutamine proteins. Polyglutamine expansion underlies various related diseaseas, including Huntington’s Disease and several other ataxias. The nature of the misfolding mechanism and the structures of the misfolded species remain poorly understood. The R01 will support our ongoing studies using magic-angle-spinning NMR (and other tools) to provide the need structural insights.