This coming week the Van der Wel lab will be represented at the annual meeting of the Biophysical Society, taking place in San Francisco. As summarized below, a recurring theme in the presented work will be the impact of oxidative damage in health and disease.
Dr. Mingyue Li will present her studies of mitochondrial protein-lipid interactions during her platform session talk on Monday Feb. 19 (1130AM; 999-PLAT). She will talk about the structure and dynamics of the cardiolipin-cytochrome c complex that is implicated in the early stages of mitochondrial apoptosis. This protein/lipid complex features a peripherally bound protein that facilitates the oxidation of poly-unsaturated cardiolipin lipids.
Jennifer Boatz will present a poster on Feb 21st (2815-Pos; B23) on her use of magic-angle-spinning NMR and electron microscopy to probe the aggregated state of apolipoprotein A1, in presence and absence of methionine oxidation. Aggregated ApoA1 is a prominent component of deposits formed during atherosclerosis. For more information see Jennifer’s poster and our in-press collaborative publication in the FASEB Journal.