On Sept 28 2021, Patrick gave a public webinar on the topic of protein Misfolding and aggregation in Huntington’s disease (and related polyglutamine disorders). This was part of the international webinar series on Cellular and Protein Homeostasis. This webinar is now available for streaming online at the following URL (updated URL in 2024). The webinar discusses some of the lessons we learned from our ongoing studies of what happens to mutated proteins in Huntington’s disease. In particular: what is the role of the mutated polyglutamine domain? How does it change its conformation as it transitions from its normal fold to a disease-causing “misfolded” state?
Title: On the role of beta-hairpins in the nucleation and propagation of polyglutamine protein aggregation.
For more information see also our recent papers in JMB (2020) and EBM (2019).