Patrick was invited to present some of our work in the P3S webinar series organised by three research groups from Europe, China and the US. This recurring series has included many interesting talks on studies of polymers and hydrogels by various spectroscopic techniques, with a recurring role for (solid-state) NMR spectroscopy. Patrick spoke about our published work on studying the repeating polymer structures of polyglutamine proteins [1] and (briefly) our newer investigations of polysaccharide hydrogels [2] . In the former topic, the talk discussed the use and benefits of torsion angle measurements by solid-state NMR, as demonstrated in our prior work on various different samples [1,3-4].
The talk was recorded and can be found in the P3S online archive, with the specific talk linked here.
- Hoop, C. L.; Lin, H.-K.; Kar, K.; Magyarfalvi, G.; Lamley, J. M.; Boatz, J. C.; Mandal, A.; Lewandowski, J. R.; Wetzel, R.; van der Wel, P. C. A. Huntingtin Exon 1 Fibrils Feature an Interdigitated β-Hairpin-Based Polyglutamine Core. Proc. Natl. Acad. Sci. USA 2016, 113 (6), 1546–1551. https://doi.org/10.1073/pnas.1521933113.
- El Hariri El Nokab, M.; van der Wel, P. C. A. Use of Solid-State NMR Spectroscopy for Investigating Polysaccharide-Based Hydrogels: A Review. Carbohydrate Polymers 2020, 116276. https://doi.org/10.1016/j.carbpol.2020.116276.
- Bajaj, V. S.; van der Wel, P. C. A.; Griffin, R. G. Observation of a Low-Temperature, Dynamically Driven Structural Transition in a Polypeptide by Solid-State NMR Spectroscopy. J Am Chem Soc 2009, 131 (1), 118–128. https://doi.org/10.1021/ja8045926.
- Van der Wel, P. C. A.; Lewandowski, J. R.; Griffin, R. G. Structural Characterization of GNNQQNY Amyloid Fibrils by Magic Angle Spinning NMR. Biochemistry 2010, 49 (44), 9457–9469. https://doi.org/10.1021/bi100077x.