Publication: Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation. (J. Mol. Biol.)

Our new publication together with our collaborators in the Wetzel and Horne groups is now available online at the Journal of Molecular Biology:

• Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation. Kar, K., Baker, M.A., Lengyel, G.A., Hoop, C.L., Kodali, R., Byeon, I-J., Horne, W.S., Van der Wel, P.C.A., and Wetzel, R., (2016) J. Mol. Biol. in press (DOI)

In this work, Karunakar Kar and co-workers (including Cody Hoop from our lab) combined various techniques to design and test designer-inhibitors against polyQ aggregation. The work highlights the value of structural and mechanistic understanding of the polyglutamine misfolding and aggregation process in such endeavors. (Some of these structural insights were derived from current and prior solid-state NMR studies.)

• Next Publication: Ultracentrifugal packing of biological MAS NMR samples.
• Previous Congratulations to Abhishek for his successful PhD defense!