The National Institutes of Health (NIH) have awarded the Van der Wel group a new R01 grant to support our research into the molecular mechanisms of mitochondrial apoptosis. Mitochondrial apoptosis is a vital cellular process required for proper development and health. However, malfunctioning of this process, e.g. undesired up- or down-regulation, plays a key role in diseases ranging from cancer to neurodegeneration, including Huntington’s Disease. In this project we investigate pivotal processes that occur early on in the apoptotic pathway, and thus may present important targets for medical intervention. A key focal point is on the role of mitochondrial membranes, and in particular the impact of changes in their structure, fluidity, and integrity. Our studies will leverage state-of-the-art ssNMR experiments, functional assays, and an array of biochemical and biophysical techniques.
Related Publications
- Structural changes and pro-apoptotic peroxidase activity of cardiolipin-bound mitochondrial cytochrome c. Mandal, A., Hoop, C.L., DeLucia, M., Kodali, R., Kagan, V., Ahn, J., Van der Wel, P.C.A.* (2015) Biophys. J. 109(9): 1873–1884 (DOI)
- Lipid Dynamics and Protein-Lipid Interactions in Integral Membrane Proteins: Insights from Solid-State NMR. Van der Wel, P.C.A.* (2014) eMagRes. 3: 111–118 (DOI) (PDF download)